Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 4B7 A 601 |
| Chain | Residue |
| A | LEU248 |
| A | MET318 |
| A | THR319 |
| A | TYR320 |
| A | GLY321 |
| A | LEU370 |
| A | PHE382 |
| A | ALA269 |
| A | LYS271 |
| A | PHE283 |
| A | MET290 |
| A | ILE313 |
| A | THR315 |
| A | GLU316 |
| A | PHE317 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | HIS361 |
| A | ASP363 |
| A | ASN368 |
| A | ALA380 |
| A | PHE382 |
| A | GLY383 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MES A 603 |
| Chain | Residue |
| A | ARG367 |
| A | PRO402 |
| A | ILE403 |
| A | LYS404 |
| A | TRP405 |
| A | LEU445 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue 4B7 B 601 |
| Chain | Residue |
| B | ALA269 |
| B | LYS271 |
| B | ILE313 |
| B | THR315 |
| B | GLU316 |
| B | PHE317 |
| B | MET318 |
| B | THR319 |
| B | GLY321 |
| B | PHE382 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| B | HIS361 |
| B | ARG362 |
| B | GLY383 |
| B | SER385 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MES B 603 |
| Chain | Residue |
| B | ARG367 |
| B | PRO402 |
| B | ILE403 |
| B | LYS404 |
| B | LEU445 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK |
| Chain | Residue | Details |
| A | LEU248-LYS271 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE359-VAL371 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ALA344 | |
| B | ALA344 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | SER229 | |
| A | GLN252 | |
| A | ASN297 | |
| B | SER229 | |
| B | GLN252 | |
| B | ASN297 | |
| Chain | Residue | Details |
| A | LYS234 | |
| A | GLU238 | |
| A | THR394 | |
| B | LYS234 | |
| B | GLU238 | |
| B | THR394 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036 |
| Chain | Residue | Details |
| A | ASN374 | |
| B | ASN374 | |
| Chain | Residue | Details |
| A | VAL427 | |
| B | VAL427 | |
