3GEQ

Structural basis for the chemical rescue of Src kinase activity

Summary for 3GEQ

• Entry DOI: 10.2210/pdb3geq/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total)
• Functional Keywords: kinase, chemical rescue, pp2, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
• Biological source: Gallus gallus (bantam,chickens)
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 65886.63

Authors

Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A. (deposition date: 2009-02-25, release date: 2009-04-28, Last modification date: 2023-09-06)

• Primary citation: Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A.; Comparative analysis of mutant tyrosine kinase chemical rescue.; Biochemistry, 48:3378-3386, 2009; PubMed: 19260709; DOI: 10.1021/bi900057g

Experimental method

X-RAY DIFFRACTION (2.2 Å)