3GEQ

Structural basis for the chemical rescue of Src kinase activity

Summary for 3GEQ

DescriptorProto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total)
Functional Keywordskinase, chemical rescue, pp2, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
Biological sourceGallus gallus (bantam,chickens)
Cellular locationCell membrane (By similarity) P00523
Total number of polymer chains2
Total molecular weight65886.63
Authors
Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A. (deposition date: 2009-02-25, release date: 2009-04-28, Last modification date: 2011-07-13)
Primary citation
Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A.
Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48:3378-3386, 2009
PubMed: 19260709 (PDB entries with the same primary citation)
DOI: 10.1021/bi900057g
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.273130.4%2.6%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution