3GEQ

Structural basis for the chemical rescue of Src kinase activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Proto-oncogene tyrosine-protein kinase Src	polymer	286	32640.5	2	UniProt (P00523) Pfam (PF07714) In PDB	Gallus gallus (bantam chickens)	pp60c-src, p60-Src, c-Src
2	A, B	1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE	non-polymer		302.8	2	Chemie (PP2)
3		water	water		18.0	221	Chemie (HOH)

Sequence modifications

A, B: 251 - 533 (UniProt: P00523)

PDB	External Database	Details
Gly 248	-	expression tag
His 249	-	expression tag
Met 250	-	expression tag
Ala 388	Arg 388	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65281.1
Non-Polymers*	Number of molecules	2
	Total formula weight	605.6
All*	Total formula weight	65886.6

*Water molecules are not included.