5WIS | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION | | Descriptor: | 23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S. | | Deposit date: | 2017-07-20 | | Release date: | 2018-02-14 | | Last modified: | 2018-03-21 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
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5WIT | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PIKROMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S. | | Deposit date: | 2017-07-20 | | Release date: | 2018-02-14 | | Last modified: | 2018-03-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
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3JQ4 | | THE STRUCTURE OF THE COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM D. RADIODURANS WITH THE ANTIBIOTIC LANKACIDIN | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide | | Authors: | Auerbach-Nevo, T., Mermershtain, I., Davidovich, C., Bashan, A., Rozenberg, H., Yonath, A. | | Deposit date: | 2009-09-06 | | Release date: | 2010-09-08 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (3.52 Å) | | Cite: | The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
Proc.Natl.Acad.Sci.USA, 107, 2010
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4WWW | | CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CEM-101 | | Descriptor: | 23S rRNA, 5S rRNA, 50S ribosomal protein L2, ... | | Authors: | Dunkle, J.A., Zhang, W., Cate, J.H.D., Mankin, A.S. | | Deposit date: | 2014-11-12 | | Release date: | 2014-12-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
Antimicrob. Agents Chemother., 54, 2010
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5O2R | | CRYO-EM STRUCTURE OF THE PROLINE-RICH ANTIMICROBIAL PEPTIDE API137 BOUND TO THE TERMINATING RIBOSOME | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Graf, M., Berninghausen, O., Beckmann, R., Wilson, D.N. | | Deposit date: | 2017-05-22 | | Release date: | 2017-07-26 | | Last modified: | 2017-09-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
Nat. Struct. Mol. Biol., 24, 2017
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