8VTU
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution
This is a non-PDB format compatible entry.
Summary for 8VTU
Entry DOI | 10.2210/pdb8vtu/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (64 entities in total) |
Functional Keywords | macrolone; macrolide; fluoroquinolone; erythromycin; ciprofloxacin; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel; multidrug; resistance; methylation; 23s rrna; a2058; erm, ribosome |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4572401.77 |
Authors | Aleksandrova, E.V.,Ma, C.-X.,Klepacki, D.,Alizadeh, F.,Vazquez-Laslop, N.,Liang, J.-H.,Polikanov, Y.S.,Mankin, A.S. (deposition date: 2024-01-27, release date: 2024-08-07) |
Primary citation | Aleksandrova, E.V.,Ma, C.X.,Klepacki, D.,Alizadeh, F.,Vazquez-Laslop, N.,Liang, J.H.,Polikanov, Y.S.,Mankin, A.S. Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nat.Chem.Biol., 2024 Cited by PubMed: 39039256DOI: 10.1038/s41589-024-01685-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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