7RQE
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution
This is a non-PDB format compatible entry.
Summary for 7RQE
Entry DOI | 10.2210/pdb7rqe/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total) |
Functional Keywords | chloramphenicol, linezolid, antibiotic, peptidyl-trna, 70s ribosome, inhibition of translation, uncompetitive inhibition, peptidyl transferase center, context-specificity of drug action, ribosome |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 112 |
Total formula weight | 4432494.75 |
Authors | Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S. (deposition date: 2021-08-06, release date: 2022-01-26, Last modification date: 2023-11-15) |
Primary citation | Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S. Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29:152-161, 2022 Cited by PubMed: 35165455DOI: 10.1038/s41594-022-00720-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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