7RQA

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution

This is a non-PDB format compatible entry.

Summary for 7RQA

• Entry DOI: 10.2210/pdb7rqa/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total)
• Functional Keywords: chloramphenicol, linezolid, antibiotic, peptidyl-trna, 70s ribosome, inhibition of translation, uncompetitive inhibition, peptidyl transferase center, context-specificity of drug action, ribosome
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 112
• Total formula weight: 4432262.38

Authors

Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S. (deposition date: 2021-08-06, release date: 2022-01-26, Last modification date: 2023-11-15)

• Primary citation: Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S.; Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.; Nat.Struct.Mol.Biol., 29:152-161, 2022; PubMed: 35165455; DOI: 10.1038/s41594-022-00720-y

Experimental method

X-RAY DIFFRACTION (2.4 Å)