3JQ4
The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin
Summary for 3JQ4
Entry DOI | 10.2210/pdb3jq4/pdb |
Related | 1NKW |
Descriptor | 23S ribosomal RNA, 5S ribosomal RNA, N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide (3 entities in total) |
Functional Keywords | ribosome structure, antibiotics, lankacidin, lankamycin, protein synthesis, inhibitors, synergism, macrolide, rna |
Biological source | Deinococcus radiodurans More |
Total number of polymer chains | 2 |
Total formula weight | 971894.31 |
Authors | Auerbach-Nevo, T.,Mermershtain, I.,Davidovich, C.,Bashan, A.,Rozenberg, H.,Yonath, A. (deposition date: 2009-09-06, release date: 2010-09-08, Last modification date: 2023-11-01) |
Primary citation | Auerbach, T.,Mermershtain, I.,Davidovich, C.,Bashan, A.,Belousoff, M.,Wekselman, I.,Zimmerman, E.,Xiong, L.,Klepacki, D.,Arakawa, K.,Kinashi, H.,Mankin, A.S.,Yonath, A. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics Proc.Natl.Acad.Sci.USA, 107:1983-1988, 2010 Cited by PubMed: 20080686DOI: 10.1073/pnas.0914100107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.52 Å) |
Structure validation
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