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7RQC

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution

This is a non-PDB format compatible entry.
Summary for 7RQC
Entry DOI10.2210/pdb7rqc/pdb
Descriptor23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (62 entities in total)
Functional Keywordschloramphenicol; linezolid; antibiotic; peptidyl-trna; 70s ribosome; x-ray structure; inhibition of translation; uncompetitive inhibition; peptidyl transferase center; context-specificity of drug action, ribosome
Biological sourceEscherichia coli K-12
More
Total number of polymer chains112
Total formula weight4432038.56
Authors
Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S. (deposition date: 2021-08-06, release date: 2022-01-26, Last modification date: 2023-11-15)
Primary citationSyroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S.
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29:152-161, 2022
Cited by
PubMed: 35165455
DOI: 10.1038/s41594-022-00720-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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