8VTW

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution

This is a non-PDB format compatible entry.

Summary for 8VTW

• Entry DOI: 10.2210/pdb8vtw/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total)
• Functional Keywords: macrolone; macrolide; fluoroquinolone; erythromycin; ciprofloxacin; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel; multidrug; resistance; methylation; 23s rrna; a2058; erm, ribosome
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 106
• Total formula weight: 4426390.44

Authors

Aleksandrova, E.V.,Ma, C.-X.,Klepacki, D.,Alizadeh, F.,Vazquez-Laslop, N.,Liang, J.-H.,Polikanov, Y.S.,Mankin, A.S. (deposition date: 2024-01-27, release date: 2024-08-07)

• Primary citation: Aleksandrova, E.V.,Ma, C.X.,Klepacki, D.,Alizadeh, F.,Vazquez-Laslop, N.,Liang, J.H.,Polikanov, Y.S.,Mankin, A.S.; Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.; Nat.Chem.Biol., 2024; PubMed: 39039256; DOI: 10.1038/s41589-024-01685-3

Experimental method

X-RAY DIFFRACTION (2.35 Å)