Author results

1RGS
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REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
分子名称:CAMP DEPENDENT PROTEIN KINASE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Su, Y., Dostmann, W.R.G., Herberg, F.W., Durick, K., Xuong, N.-H., Ten Eyck, L., Taylor, S.S., Varughese, K.I.
登録日1995-06-21
公開日1996-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science, 269, 1995
3U0Z
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TETRAMERIZATION DYNAMICS OF THE C-TERMINUS UNDERLIES ISOFORM-SPECIFIC CAMP-GATING IN HCN CHANNELS
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Lolicato, M., Nardini, M., Gazzarrini, S., Moller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
3U10
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TETRAMERIZATION DYNAMICS OF THE C-TERMINUS UNDERLIES ISOFORM-SPECIFIC CAMP-GATING IN HCN CHANNELS
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Lolicato, M., Nardini, M., Gazzarrini, S., Moller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
3U11
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TETRAMERIZATION DYNAMICS OF THE C-TERMINUS UNDERLIES ISOFORM-SPECIFIC CAMP-GATING IN HCN CHANNELS
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL
著者Lolicato, M., Nardini, M., Gazzarrini, S., Moller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
4KU7
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STRUCTURES OF PKGI REVEAL A CGMP-SELECTIVE ACTIVATION MECHANISM
分子名称:cGMP-dependent protein kinase 1, IODIDE ION, CYCLIC GUANOSINE MONOPHOSPHATE
著者Huang, G.Y., Kim, J.J., Reger, A.S., Lorenz, R., Moon, E.W., Casteel, D.E., Sankaran, B., Herberg, F.W., Kim, C.
登録日2013-05-21
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
Structure, 22, 2014
4KU8
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STRUCTURES OF PKGI REVEAL A CGMP-SELECTIVE ACTIVATION MECHANISM
分子名称:cGMP-dependent Protein Kinase 1, GLYCINE
著者Huang, G.Y., Kim, J.J., Reger, A.S., Lorenz, R., Moon, E.W., Casteel, D.E., Sankaran, B., Herberg, F.W., Kim, C.
登録日2013-05-21
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
Structure, 22, 2014
4WBB
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SINGLE TURNOVER AUTOPHOSPHORYLATION CYCLE OF THE PKA RIIB HOLOENZYME
分子名称:cAMP-dependent protein kinase type II-beta regulatory subunit, cAMP-dependent protein kinase catalytic subunit alpha, CALCIUM ION, ...
著者Zhang, P., Knape, M.J., Ahuja, L.G., Keshwani, M.M., King, C.C., Sastri, M., Herberg, F.W., Taylor, S.S.
登録日2014-09-02
公開日2015-05-20
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme.
Plos Biol., 13, 2015
4ZP3
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AKAP18:PKA-RIIALPHA STRUCTURE REVEALS CRUCIAL ANCHOR POINTS FOR RECOGNITION OF REGULATORY SUBUNITS OF PKA
分子名称:cAMP-dependent protein kinase type II-alpha regulatory subunit, A-kinase anchor protein 7 isoforms alpha and beta, CADMIUM ION
著者Goetz, F., Roske, Y., Faelber, K., Zuehlke, K., Autenrieth, K., Kreuchwig, A., Krause, G., Herberg, F.W., Daumke, O., Heinemann, U., Klussmann, E.
登録日2015-05-07
公開日2016-05-04
最終更新日2016-07-06
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献AKAP18:PKA-RII alpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA.
Biochem.J., 473, 2016
5KJX
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CO-CRYSTAL STRUCTURE OF PKA RI ALPHA CNB-B DOMAIN WITH CAMP
分子名称:cAMP-dependent protein kinase type I-alpha regulatory subunit, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Lorenz, R., Moon, E., Kim, J.J., Huang, G.Y., Kim, C., Herberg, F.W.
登録日2016-06-20
公開日2017-06-28
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
Biochem. J., 474, 2017
5KJY
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CO-CRYSTAL STRUCTURE OF PKA RI ALPHA CNB-B MUTANT (G316R/A336T) WITH CAMP
分子名称:cAMP-dependent protein kinase type I-alpha regulatory subunit, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Lorenz, R., Moon, E., Kim, J.J., Huang, G.Y., Kim, C., Herberg, F.W.
登録日2016-06-20
公開日2017-06-28
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
Biochem. J., 474, 2017
5KJZ
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CO-CRYSTAL STRUCTURE OF PKA RI ALPHA CNB-B MUTANT (G316R/A336T) WITH CGMP
分子名称:cAMP-dependent protein kinase type I-alpha regulatory subunit, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL
著者Lorenz, R., Moon, E., Kim, J.J., Huang, G.Y., Kim, C., Herberg, F.W.
登録日2016-06-20
公開日2017-06-28
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.347 Å)
主引用文献Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
Biochem. J., 474, 2017
3ZU7
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CRYSTAL STRUCTURE OF A DESIGNED SELECTED ANKYRIN REPEAT PROTEIN IN COMPLEX WITH THE MAP KINASE ERK2
分子名称:MITOGEN-ACTIVATED PROTEIN KINASE 1, DESIGNED ANKYRIN REPEAT PROTEIN
著者Kummer, L., Mittl, P.R., Pluckthun, A.
登録日2011-07-16
公開日2012-06-27
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Proc.Natl.Acad.Sci.USA, 109, 2012
3ZUV
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CRYSTAL STRUCTURE OF A DESIGNED SELECTED ANKYRIN REPEAT PROTEIN IN COMPLEX WITH THE PHOSPHORYLATED MAP KINASE ERK2
分子名称:MITOGEN-ACTIVATED PROTEIN KINASE 1, DESIGNED ANKYRIN REPEAT PROTEIN, SULFATE ION
著者Kummer, L., Mittl, P.R., Pluckthun, A.
登録日2011-07-20
公開日2012-06-27
最終更新日2012-09-05
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Proc.Natl.Acad.Sci.USA, 109, 2012
4C57
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STRUCTURE OF GAK KINASE IN COMPLEX WITH A NANOBODY
分子名称:Cyclin-G-associated kinase, NANOBODY, SULFATE ION, ...
著者Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
登録日2013-09-10
公開日2013-10-09
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of Cyclin G-Associated Kinase (Gak) Trapped in Different Conformations Using Nanobodies.
Biochem.J., 459, 2014
4C58
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STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4)
分子名称:Cyclin-G-associated kinase, nanobody, 1,2-ETHANEDIOL, ...
著者Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
登録日2013-09-10
公開日2013-10-09
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
4C59
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STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4)
分子名称:Cyclin-G-associated kinase, NANOBODY, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
著者Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
登録日2013-09-10
公開日2013-10-09
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
4NVP
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STRUCTURE OF THE CYCLIC NUCLEOTIDE-BINDING DOMAIN OF HCN4 CHANNEL COMPLEXED WITH 7-CH-CAMP
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
著者Alfieri, A., Moroni, A.
登録日2013-12-05
公開日2014-03-19
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
4OFF
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CRYSTAL STRUCTURE OF APO CARBOXY CGMP BINDING DOMAIN OF PLASMODIUM FALCIPARUM PKG
分子名称:CGMP-dependent protein kinase, SULFATE ION
著者Kim, J.J., Sanabria figueroa, E., Kim, C.
登録日2014-01-14
公開日2015-01-21
最終更新日2015-02-11
実験手法X-RAY DIFFRACTION (1.888 Å)
主引用文献Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Plos Pathog., 11, 2015
4OFG
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CO-CRYSTAL STRUCTURE OF CARBOXY CGMP BINDING DOMAIN OF PLASMODIUM FALCIPARUM PKG WITH CGMP
分子名称:CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE, PENTANE-1,5-DIAMINE, ...
著者Kim, J.J., Sanabria figueroa, E., Kim, C.
登録日2014-01-14
公開日2015-01-21
最終更新日2015-02-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Plos Pathog., 11, 2015
4Z07
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CO-CRYSTAL STRUCTURE OF THE TANDEM CNB (CNB-A/B) DOMAINS OF HUMAN PKG I BETA WITH CGMP
分子名称:cGMP-dependent protein kinase 1, CYCLIC GUANOSINE MONOPHOSPHATE, SULFATE ION, ...
著者Kim, J.J., Reger, A.S., Arold, S.T., Kim, C.
登録日2015-03-25
公開日2016-04-13
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
Structure, 24, 2016
5J48
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PKG I'S CARBOYL TERMINAL CYCLIC NUCLEOTIDE BINDING DOMAIN (CNB-B) IN A COMPLEX WITH 8-PCPT-CGMP
分子名称:cGMP-dependent protein kinase 1, 1,2-ETHANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, ...
著者Campbell, J.C., Sankaran, B., Kim, C.W.
登録日2016-03-31
公開日2017-04-12
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Structural Basis of Analog Specificity in PKG I and II.
ACS Chem. Biol., 12, 2017
5JAX
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PKG I'S CARBOYL TERMINAL CYCLIC NUCLEOTIDE BINDING DOMAIN (CNB-B) IN A COMPLEX WITH 8-BR-CGMP
分子名称:cGMP-dependent protein kinase 1, 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ...
著者Campbell, J.C., Sankaran, B., Kim, C.W.
登録日2016-04-12
公開日2017-04-19
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.486 Å)
主引用文献Structural Basis of Analog Specificity in PKG I and II.
ACS Chem. Biol., 12, 2017
5JD7
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PKG I'S CARBOXYL TERMINAL CYCLIC NUCLEOTIDE BINDING DOMAIN (CNB-B) IN A COMPLEX WITH PET-CGMP
分子名称:cGMP-dependent protein kinase 1, 3-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one
著者Campbell, J.C., Sankaran, B., Kim, C.W.
登録日2016-04-15
公開日2017-08-09
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献Structural Basis of Analog Specificity in PKG I and II.
ACS Chem. Biol., 12, 2017
5JIX
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PKG II'S CARBOXYL TERMINAL CYCLIC NUCLEOTIDE BINDING DOMAIN (CNB-B) IN A COMPLEX WITH 8-BR-CGMP
分子名称:cGMP-dependent protein kinase 2, CALCIUM ION, 1,2-ETHANEDIOL, ...
著者Campbell, J.C., Kim, C.W.
登録日2016-04-22
公開日2017-05-03
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Structural Basis of Analog Specificity in PKG I and II.
ACS Chem. Biol., 12, 2017
6EXI
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NAD-FREE CRYSTAL STRUCTURE OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM BRADYRHIZOBIUM ELKANII COMPLEXED WITH ADENOSINE
分子名称:Adenosylhomocysteinase, SODIUM ION, ADENOSINE, ...
著者Manszewski, T., Jaskolski, M.
登録日2017-11-08
公開日2018-09-19
実験手法X-RAY DIFFRACTION (1.918 Å)
主引用文献S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic.
Front Microbiol, 9, 2018
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