4KU7

Structures of PKGI Reveal a cGMP-Selective Activation Mechanism

Summary for 4KU7

Entry DOI	10.2210/pdb4ku7/pdb
Related	4KU8
Descriptor	cGMP-dependent protein kinase 1, IODIDE ION, CYCLIC GUANOSINE MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	cyclic nucleotide binding domain, cgmp, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q13976
Total number of polymer chains	1
Total formula weight	20336.72
Authors	Huang, G.Y.,Kim, J.J.,Reger, A.S.,Lorenz, R.,Moon, E.W.,Casteel, D.E.,Sankaran, B.,Herberg, F.W.,Kim, C. (deposition date: 2013-05-21, release date: 2014-01-15, Last modification date: 2024-02-28)
Primary citation	Huang, G.Y.,Kim, J.J.,Reger, A.S.,Lorenz, R.,Moon, E.W.,Zhao, C.,Casteel, D.E.,Bertinetti, D.,Vanschouwen, B.,Selvaratnam, R.,Pflugrath, J.W.,Sankaran, B.,Melacini, G.,Herberg, F.W.,Kim, C. Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I. Structure, 22:116-124, 2014 Cited by PubMed: 24239458 DOI: 10.1016/j.str.2013.09.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation