4KU7

Structures of PKGI Reveal a cGMP-Selective Activation Mechanism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004692	molecular_function	cGMP-dependent protein kinase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 401

Chain	Residue
A	ASP334
A	HOH505
A	HOH560

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 402

Chain	Residue
A	GLU254
A	IOD407
A	HOH521

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 403

Chain	Residue
A	GLN311
A	GLY341
A	SER347

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 404

Chain	Residue
A	HIS338

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 405

Chain	Residue
A	ASP334
A	LYS337

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 406

Chain	Residue
A	HOH542
A	HOH542

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 407

Chain	Residue
A	GLN266
A	ARG316
A	IOD402

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 409

Chain	Residue
A	SER277
A	HOH551

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 410

Chain	Residue
A	LYS308
A	GLN311
A	GLU313
A	IOD423
A	HOH509
A	HOH565

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 411

Chain	Residue
A	GLU242
A	SER246
A	IOD421
A	HOH502

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 412

Chain	Residue
A	IOD421
A	HOH514

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IOD A 413

Chain	Residue
A	PRO241
A	TYR257
A	ILE263
A	IOD415
A	IOD419

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 414

Chain	Residue
A	TYR262
A	THR284
A	PRO293

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IOD A 415

Chain	Residue
A	GLU243
A	TYR257
A	TYR262
A	IOD413
A	HOH529

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 416

Chain	Residue
A	TYR262
A	ARG265
A	HOH541

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 417

Chain	Residue
A	LYS232
A	ARG269
A	ASP271
A	ASP314

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 418

Chain	Residue
A	GLU242
A	ASP271
A	THR272
A	HOH511

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 419

Chain	Residue
A	PRO241
A	GLU242
A	GLU243
A	ILE263
A	IOD413
A	IOD420

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 420

Chain	Residue
A	GLU242
A	ILE264
A	ARG265
A	ALA268
A	IOD419
A	IOD421

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IOD A 421

Chain	Residue
A	GLU243
A	ALA268
A	IOD411
A	IOD412
A	IOD420

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 423

Chain	Residue
A	LYS308
A	GLU313
A	VAL315
A	THR317
A	IOD410
A	HOH521

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 424

Chain	Residue
A	LEU310
A	LEU310
A	GLN311
A	GLN311
A	GLY312
A	GLY312

---

site_id	CC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PCG A 425

Chain	Residue
A	ILE264
A	LEU296
A	ARG297
A	PHE305
A	GLY306
A	GLU307
A	LYS308
A	ALA309
A	ARG316
A	THR317
A	ALA318
A	VAL320
A	TYR351
A	HOH517

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrQGArGDtFFIIskG

Chain	Residue	Details
A	ILE263-GLY279

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEkALqgedv......RTAnViA

Chain	Residue	Details
A	PHE305-ALA322

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24239458, ECO:0000269|PubMed:25271401, ECO:0007744|PDB:4KU7, ECO:0007744|PDB:4QXK

Chain	Residue	Details
A	ARG297
A	GLY306
A	ARG316
A	TYR351

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