4KU8

Structures of PKGI Reveal a cGMP-Selective Activation Mechanism

Summary for 4KU8

• Entry DOI: 10.2210/pdb4ku8/pdb
• Related: 4KU7
• Descriptor: cGMP-dependent Protein Kinase 1, GLYCINE (3 entities in total)
• Functional Keywords: cyclic nucleotide binding domain, cgmp, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q13976
• Total number of polymer chains: 3
• Total formula weight: 51062.65

Authors

Huang, G.Y.,Kim, J.J.,Reger, A.S.,Lorenz, R.,Moon, E.W.,Casteel, D.E.,Sankaran, B.,Herberg, F.W.,Kim, C. (deposition date: 2013-05-21, release date: 2014-01-15, Last modification date: 2024-02-28)

• Primary citation: Huang, G.Y.,Kim, J.J.,Reger, A.S.,Lorenz, R.,Moon, E.W.,Zhao, C.,Casteel, D.E.,Bertinetti, D.,Vanschouwen, B.,Selvaratnam, R.,Pflugrath, J.W.,Sankaran, B.,Melacini, G.,Herberg, F.W.,Kim, C.; Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.; Structure, 22:116-124, 2014; PubMed: 24239458; DOI: 10.1016/j.str.2013.09.021

Experimental method

X-RAY DIFFRACTION (1.994 Å)