4KU8
Structures of PKGI Reveal a cGMP-Selective Activation Mechanism
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004692 | molecular_function | cGMP-dependent protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| B | 0004692 | molecular_function | cGMP-dependent protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| C | 0004692 | molecular_function | cGMP-dependent protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GLY A 401 |
| Chain | Residue |
| A | GLU226 |
| A | GLU229 |
| A | PHE230 |
| A | HOH549 |
| A | HOH572 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GLY A 402 |
| Chain | Residue |
| A | VAL346 |
| A | ALA350 |
| A | HOH558 |
| A | HOH628 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GLY B 401 |
| Chain | Residue |
| A | GLY217 |
| A | SER218 |
| A | LEU221 |
| B | ARG297 |
| B | THR298 |
| B | HOH534 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrQGArGDtFFIIskG |
| Chain | Residue | Details |
| A | ILE263-GLY279 |
| site_id | PS00889 |
| Number of Residues | 18 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEkALqgedv......RTAnViA |
| Chain | Residue | Details |
| A | PHE305-ALA322 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | Region: {"description":"cGMP-binding, low affinity"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24239458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25271401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QXK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
