4C59
Structure of GAK kinase in complex with nanobody (NbGAK_4)
Summary for 4C59
Entry DOI | 10.2210/pdb4c59/pdb |
Related | 4C57 4C58 |
Descriptor | Cyclin-G-associated kinase, NANOBODY, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, ... (4 entities in total) |
Functional Keywords | transferase, kinase, conformational plasticity, activation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 53634.44 |
Authors | Chaikuad, A.,Keates, T.,Allerston, C.K.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Muller-Knapp, S. (deposition date: 2013-09-10, release date: 2013-10-09, Last modification date: 2023-12-20) |
Primary citation | Chaikuad, A.,Keates, T.,Vincke, C.,Kaufholz, M.,Zenn, M.,Zimmermann, B.,Gutierrez, C.,Zhang, R.G.,Hatzos-Skintges, C.,Joachimiak, A.,Muyldermans, S.,Herberg, F.W.,Knapp, S.,Muller, S. Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. Biochem. J., 459:59-69, 2014 Cited by PubMed: 24438162DOI: 10.1042/BJ20131399 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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