5JAX

PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP

Summary for 5JAX

Entry DOI	10.2210/pdb5jax/pdb
Descriptor	cGMP-dependent protein kinase 1, 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ... (5 entities in total)
Functional Keywords	binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, analogs, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q13976
Total number of polymer chains	1
Total formula weight	15513.99
Authors	Campbell, J.C.,Sankaran, B.,Kim, C.W. (deposition date: 2016-04-12, release date: 2017-04-19, Last modification date: 2023-09-27)
Primary citation	Campbell, J.C.,Henning, P.,Franz, E.,Sankaran, B.,Herberg, F.W.,Kim, C. Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12:2388-2398, 2017 Cited by PubMed: 28793191 DOI: 10.1021/acschembio.7b00369 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.486 Å)

Structure validation