3U0Z

Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels

Summary for 3U0Z

Entry DOI	10.2210/pdb3u0z/pdb
Related	1Q43 3OTF 3U10 3U11
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (3 entities in total)
Functional Keywords	helix, beta sheet, transport protein, cnmp binding
Biological source	Mus musculus (mouse)
Cellular location	Membrane; Multi-pass membrane protein: O88704
Total number of polymer chains	2
Total formula weight	49720.65
Authors	Lolicato, M.,Nardini, M.,Gazzarrini, S.,Moller, S.,Bertinetti, D.,Herberg, F.W.,Bolognesi, M.,Martin, H.,Fasolini, M.,Bertrand, J.A.,Arrigoni, C.,Thiel, G.,Moroni, A. (deposition date: 2011-09-29, release date: 2011-10-26, Last modification date: 2023-11-01)
Primary citation	Lolicato, M.,Nardini, M.,Gazzarrini, S.,Moller, S.,Bertinetti, D.,Herberg, F.W.,Bolognesi, M.,Martin, H.,Fasolini, M.,Bertrand, J.A.,Arrigoni, C.,Thiel, G.,Moroni, A. Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J.Biol.Chem., 286:44811-44820, 2011 Cited by PubMed: 22006928 DOI: 10.1074/jbc.M111.297606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation