1Q43

HCN2I 443-640 in the presence of cAMP, selenomethionine derivative

Summary for 1Q43

Entry DOI	10.2210/pdb1q43/pdb
Related	1Q3E 1Q5O
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (3 entities in total)
Functional Keywords	cnbd, c-linker, pacemaker, hcn, hcn2, channel, cyclic nucleotide, cap, pka, camp, ion channel, ligand, transport protein
Biological source	Mus musculus (house mouse)
Cellular location	Membrane; Multi-pass membrane protein: O88703
Total number of polymer chains	2
Total formula weight	49794.30
Authors	Zagotta, W.N.,Olivier, N.B.,Black, K.D.,Young, E.C.,Olson, R.,Gouaux, J.E. (deposition date: 2003-08-01, release date: 2003-09-09, Last modification date: 2011-07-13)
Primary citation	Zagotta, W.N.,Olivier, N.B.,Black, K.D.,Young, E.C.,Olson, R.,Gouaux, J.E. Structural basis for modulation and agonist specificity of HCN pacemaker channels Nature, 425:200-205, 2003 Cited by PubMed: 12968185 DOI: 10.1038/nature01922 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation