1Q43

HCN2I 443-640 in the presence of cAMP, selenomethionine derivative

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	polymer	207	24567.9	2	UniProt (O88703) Pfam (PF00027)	Mus musculus (house mouse)	Brain cyclic nucleotide gated channel 2, BCNG-2, Hyperpolarization-activated cation channel 1, HAC-1
2	C, D (A, B)	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE	non-polymer		329.2	2	Chemie (CMP) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (176488666) PubChem (25322946) PubChem (59350541) PubChem (274) PubChem (56973690) PubChem (59909322) PubChem (59968988) PubChem (6604194) PubChem (70878457) PubChem (6076) PubChem (216878) PubChem (163043517) PubChem (3080770) PubChem (3246347) PubChem (124132380) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (12071879) PubChem (12866365) PubChem (163043518)
3	E, F (A, B)	water	water		18.0	485	Chemie (HOH)

Sequence modifications

A, B: 443 - 645 (UniProt: O88703)

PDB	External Database	Details
Gly 439	-	cloning artifact
Ser 440	-	cloning artifact
Ala 441	-	cloning artifact
Met 442	-	cloning artifact
Mse 460	Met 460	modified residue
Mse 485	Met 485	modified residue
Mse 515	Met 515	modified residue
Mse 529	Met 529	modified residue
Mse 554	Met 554	modified residue
Mse 572	Met 572	modified residue
Mse 620	Met 620	modified residue
Mse 621	Met 621	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49135.9
Non-Polymers*	Number of molecules	2
	Total formula weight	658.4
All*	Total formula weight	49794.3

*Water molecules are not included.