3U0Z
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | polymer | 210 | 24531.1 | 2 | UniProt (O88704) Pfam (PF00027) | Mus musculus (mouse) | Brain cyclic nucleotide-gated channel 1, BCNG-1, Hyperpolarization-activated cation channel 2, HAC-2 |
| 2 | C, D (A, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 2 | Chemie (CMP) PubChem (6076) PubChem (176488666) PubChem (216878) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (25322946) PubChem (3080770) PubChem (56973690) PubChem (3246347) PubChem (59909322) PubChem (59968988) PubChem (59350541) PubChem (70878457) PubChem (274) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (12071879) PubChem (12866365) PubChem (6604194) PubChem (124132380) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (163043517) PubChem (138107790) PubChem (163043518) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A, B: 390 - 592 (UniProt: O88704)
| PDB | External Database | Details |
|---|---|---|
| Gln 383 | - | expression tag |
| Gly 384 | - | expression tag |
| Pro 385 | - | expression tag |
| Ser 386 | - | expression tag |
| Ser 387 | - | expression tag |
| Pro 388 | - | expression tag |
| Met 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49062.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 658.4 | |
| All* | Total formula weight | 49720.6 |
