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4Z07

Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP

Summary for 4Z07
Entry DOI10.2210/pdb4z07/pdb
DescriptorcGMP-dependent protein kinase 1, CYCLIC GUANOSINE MONOPHOSPHATE, SULFATE ION, ... (5 entities in total)
Functional Keywordscgmp-binding domains, cgmp mediated dimeric interface, allosteric regulatory domain, serine-threonine kinase, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total formula weight89930.95
Authors
Kim, J.J.,Reger, A.S.,Arold, S.T.,Kim, C. (deposition date: 2015-03-25, release date: 2016-04-13, Last modification date: 2023-09-27)
Primary citationKim, J.J.,Lorenz, R.,Arold, S.T.,Reger, A.S.,Sankaran, B.,Casteel, D.E.,Herberg, F.W.,Kim, C.
Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
Structure, 24:710-720, 2016
Cited by
PubMed: 27066748
DOI: 10.1016/j.str.2016.03.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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