4Z07
Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP
Summary for 4Z07
Entry DOI | 10.2210/pdb4z07/pdb |
Descriptor | cGMP-dependent protein kinase 1, CYCLIC GUANOSINE MONOPHOSPHATE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | cgmp-binding domains, cgmp mediated dimeric interface, allosteric regulatory domain, serine-threonine kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 89930.95 |
Authors | Kim, J.J.,Reger, A.S.,Arold, S.T.,Kim, C. (deposition date: 2015-03-25, release date: 2016-04-13, Last modification date: 2023-09-27) |
Primary citation | Kim, J.J.,Lorenz, R.,Arold, S.T.,Reger, A.S.,Sankaran, B.,Casteel, D.E.,Herberg, F.W.,Kim, C. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure, 24:710-720, 2016 Cited by PubMed: 27066748DOI: 10.1016/j.str.2016.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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