Author results

3FDL
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BIM BH3 PEPTIDE IN COMPLEX WITH BCL-XL
Descriptor:Apoptosis regulator Bcl-X, Bcl-2-like protein 11
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J., Czabotar, P.E., Colman, P.M.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
3FDM
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ALPHA/BETA FOLDAMER IN COMPLEX WITH BCL-XL
Descriptor:Apoptosis regulator Bcl-X, alpha/beta-peptide foldamer, 1,2-ETHANEDIOL
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J., Czabotar, P.E., Colman, P.M., Sadowsky, J.D., Peterson-Kaufman, K.J., Gellman, S.H.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
3INQ
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH W1191542
Descriptor:Bcl-2-like protein 1, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, 1,2-ETHANEDIOL, ...
Authors:Fairlie, W.D., Smith, B.J., Colman, P.M., Czabotar, P.E., Lee, E.F.
Deposit date:2009-08-12
Release date:2009-09-01
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
J. Biol. Chem., 284, 2009
5FMI
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HUMAN BAK Q77L
Descriptor:BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ZINC ION
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMJ
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BCL-XL WITH MOUSE BAK BH3 Q75L COMPLEX
Descriptor:BCL-2-LIKE PROTEIN 1, BAK1 PROTEIN, 1,2-ETHANEDIOL
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMK
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BCL-XL WITH BAK BH3 COMPLEX
Descriptor:BCL-XL, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, GLYCEROL
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J., Czabotar, P.E., Colman, P.M.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.731 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
1K0M
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CRYSTAL STRUCTURE OF A SOLUBLE MONOMERIC FORM OF CLIC1 AT 1.4 ANGSTROMS
Descriptor:CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Harrop, S.J., DeMaere, M.Z., Fairlie, W.D., Reztsova, T., Valenzuela, S.M., Mazzanti, M., Tonini, R., Qiu, M.R., Jankova, L., Warton, K., Bauskin, A.R., Wu, W.M., Pankhurst, S., Campbell, T.J., Breit, S.N., Curmi, P.M.G.
Deposit date:2001-09-19
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1K0N
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CHLORIDE INTRACELLULAR CHANNEL 1 (CLIC1) COMPLEXED WITH GLUTATHIONE
Descriptor:CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1, GLUTATHIONE
Authors:Harrop, S.J., DeMaere, M.Z., Fairlie, W.D., Reztsova, T., Valenzuela, S.M., Mazzanti, M., Tonini, R., Qiu, M.R., Jankova, L., Warton, K., Bauskin, A.R., Wu, W.M., Pankhurst, S., Campbell, T.J., Breit, S.N., Curmi, P.M.G.
Deposit date:2001-09-19
Release date:2001-12-12
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1K0O
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CRYSTAL STRUCTURE OF A SOLUBLE FORM OF CLIC1. AN INTRACELLULAR CHLORIDE ION CHANNEL
Descriptor:CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Harrop, S.J., DeMaere, M.Z., Fairlie, W.D., Reztsova, T., Valenzuela, S.M., Mazzanti, M., Tonini, R., Qiu, M.R., Jankova, L., Warton, K., Bauskin, A.R., Wu, W.M., Pankhurst, S., Campbell, T.J., Breit, S.N., Curmi, P.M.G.
Deposit date:2001-09-19
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1RK4
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CRYSTAL STRUCTURE OF A SOLUBLE DIMERIC FORM OF OXIDISED CLIC1
Descriptor:CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Littler, D.R., Harrop, S.J., Fairlie, W.D., Brown, L.J., Pankhurst, G.J., Pankhurst, S., DeMaere, M.Z., Campbell, T.J., Bauskin, A.R., Tonini, R., Mazzanti, M., Breit, S.N., Curmi, P.M.
Deposit date:2003-11-20
Release date:2003-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition
J.Biol.Chem., 279, 2004
2JBX
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CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L
Descriptor:M11L PROTEIN
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JBY
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A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO- SURVIVAL BCL-2
Descriptor:M11L PROTEIN, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2, SODIUM ION
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol. Cell, 25, 2007
2JM6
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAB
Descriptor:Noxa, Myeloid cell leukemia-1 protein Mcl-1 homolog
Authors:Czabotar, P.E., Lee, E.F., van Delft, M.F., Day, C.L., Smith, B.J., Huang, D.C.S., Fairlie, W.D., Hinds, M.G., Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2ROC
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH PUMA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-binding component 3
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
2ROD
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
2VTY
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VACCINIA VIRUS ANTI-APOPTOTIC F1L IS A NOVEL BCL-2-LIKE DOMAIN SWAPPED DIMER
Descriptor:PROTEIN F1
Authors:Kvansakul, M., Yang, H., Fairlie, W.D., Czabotar, P.E., Fischer, S.F., Perugini, M.A., Huang, D.C.S., Colman, P.M.
Deposit date:2008-05-19
Release date:2008-06-24
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Vaccinia Virus Anti-Apoptotic F1L is a Novel Bcl-2-Like Domain-Swapped Dimer that Binds a Highly Selective Subset of Bh3-Containing Death Ligands.
Cell Death Differ., 15, 2008
2Y6W
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STRUCTURE OF A BCL-W DIMER
Descriptor:BCL-2-LIKE PROTEIN 2, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL
Authors:Lee, E.F., Evangelista, M., Pettikiriarachchi, A., Dogovski, C., Perugini, M.A., Colman, P.M., Fairlie, W.D.
Deposit date:2011-01-27
Release date:2011-10-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Bcl-W Domain-Swapped Dimer: Implications for the Function of Bcl-2 Family Proteins.
Structure, 19, 2011
2YJ1
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PUMA BH3 FOLDAMER IN COMPLEX WITH BCL-XL
Descriptor:BCL-2-LIKE PROTEIN 1, ALPHA-BETA-PUMA BH3 FOLDAMER
Authors:Lee, E.F., Smith, B.J., Horne, W.S., Mayer, K.N., Evangelista, M., Colman, P.M., Gellman, S.H., Fairlie, W.D.
Deposit date:2011-05-18
Release date:2011-10-12
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design
Chembiochem, 12, 2011
2YXJ
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH ABT-737
Descriptor:Apoptosis regulator Bcl-X, CHLORIDE ION, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, ...
Authors:Czabotar, P.E., Lee, E.F., Smith, B.J., Deshayes, K., Zobel, K., Fairlie, W.D., Colman, P.M.
Deposit date:2007-04-26
Release date:2007-05-22
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
3D7V
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH AN MCL-1 SELECTIVE BH3 LIGAND
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
Authors:Lee, E.F., Czabotar, P.E., Colman, P.M., Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
3IO8
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BIML12F IN COMPLEX WITH BCL-XL
Descriptor:Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D., Smith, B.J., Czabotar, P.E., Yang, H., Sleebs, B.E., Lessene, G.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3IO9
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BIML12Y IN COMPLEX WITH MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
Authors:Czabotar, P.E., Lee, E.F., Yang, H., Sleebs, B.E., Lessene, G., Colman, P.M., Smith, B.J., Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3QBR
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BAKBH3 IN COMPLEX WITH SJA
Descriptor:SJCHGC06286 protein, Bcl-2 homologous antagonist/killer, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Lee, E.F., Clarke, O.B., Fairlie, W.D., Colman, P.M., Evangelista, M., Feng, Z., Speed, T.P., Tchoubrieva, E., Strasser, A., Kalinna, B.
Deposit date:2011-01-13
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
4A1U
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CRYSTAL STRUCTURE OF ALPHA-BETA-FOLDAMER 2C IN COMPLEX WITH BCL-XL
Descriptor:BCL-2-LIKE PROTEIN 1, ALPHA-BETA-FOLDAMER 2C, CHLORIDE ION, ...
Authors:Boersma, M.D., Haase, H.S., Kaufman, K.J., Horne, W.S., Lee, E.F., Clarke, O.B., Smith, B.J., Colman, P.M., Gellman, S.H., Fairlie, W.D.
Deposit date:2011-09-20
Release date:2011-12-28
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
4A1W
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CRYSTAL STRUCTURE OF ALPHA-BETA FOLDAMER 4C IN COMPLEX WITH BCL-XL
Descriptor:BCL-2-LIKE PROTEIN 1, ALPHA-BETA-FOLDAMER 2C
Authors:Boersma, M.D., Haase, H.S., Kaufman, K.J., Horne, W.S., Lee, E.F., Clarke, O.B., Smith, B.J., Colman, P.M., Gellman, S.H., Fairlie, W.D.
Deposit date:2011-09-20
Release date:2011-12-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
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