3INQ
Crystal structure of BCL-XL in complex with W1191542
Summary for 3INQ
Entry DOI | 10.2210/pdb3inq/pdb |
Related | 2P1L 2YXJ 3FDL 3IO8 3IO9 |
Descriptor | Bcl-2-like protein 1, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | apoptosis, alternative splicing, membrane, mitochondrion, nucleus, transmembrane |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 2 |
Total formula weight | 38112.08 |
Authors | Fairlie, W.D.,Smith, B.J.,Colman, P.M.,Czabotar, P.E.,Lee, E.F. (deposition date: 2009-08-12, release date: 2009-09-01, Last modification date: 2023-11-01) |
Primary citation | Lee, E.F.,Czabotar, P.E.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D. Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands J. Biol. Chem., 284:30508-30517, 2009 Cited by PubMed: 19726685DOI: 10.1074/jbc.M109.040725 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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