3IO8

BimL12F in complex with Bcl-xL

Summary for 3IO8

Entry DOI	10.2210/pdb3io8/pdb
Related	1PQ1 3FDL 3IO9
Descriptor	Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION, ... (4 entities in total)
Functional Keywords	helical bundle, bcl-2-like fold, alternative splicing, apoptosis, membrane, mitochondrion, nucleus, transmembrane, phosphoprotein
Biological source	Homo sapiens (human) More
Cellular location	Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
Total number of polymer chains	4
Total formula weight	42649.56
Authors	Colman, P.M.,Lee, E.F.,Fairlie, W.D.,Smith, B.J.,Czabotar, P.E.,Yang, H.,Sleebs, B.E.,Lessene, G. (deposition date: 2009-08-14, release date: 2009-09-01, Last modification date: 2023-09-06)
Primary citation	Lee, E.F.,Czabotar, P.E.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D. Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J.Biol.Chem., 284:30508-30517, 2009 Cited by PubMed: 19726685 DOI: 10.1074/jbc.M109.040725 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation