2ROD

Solution Structure of MCL-1 Complexed with NoxaA

Summary for 2ROD

Related1WSX 2JM6 2ROC
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa (2 entities in total)
Functional Keywordsmcl-1, noxaa, apoptosis, bh3-only, bcl-2, cytoplasm, developmental protein, differentiation, membrane, mitochondrion, nucleus, phosphoprotein, transmembrane, ubl conjugation
Biological sourceMus musculus (Mouse)
Cellular locationMembrane; Single-pass membrane protein (By similarity) P97287
Mitochondrion Q9JM54
Total number of polymer chains2
Total molecular weight21301.16
Authors
Day, C.L.,Smits, C.,Fan, F.C.,Lee, E.F.,Fairlie, W.D.,Hinds, M.G. (deposition date: 2008-03-17, release date: 2008-07-08, Last modification date: 2011-07-13)
Primary citation
Day, C.L.,Smits, C.,Fan, F.C.,Lee, E.F.,Fairlie, W.D.,Hinds, M.G.
Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380:958-971, 2008
PubMed: 18589438 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.05.071
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers80.1%13.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2rod
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Molmil generated image of 2rod
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Molmil generated image of 2rod
rotated about y axis by 90°