2JM6
Solution structure of MCL-1 complexed with NOXAB
Summary for 2JM6
Entry DOI | 10.2210/pdb2jm6/pdb |
Related | 1WSX |
Descriptor | Noxa, Myeloid cell leukemia-1 protein Mcl-1 homolog (2 entities in total) |
Functional Keywords | apoptosis, mcl-1, bcl-2, helical bundle, bh3-only |
Biological source | Mus musculus (house mouse) More |
Cellular location | Mitochondrion: Q9JM54 Membrane; Single-pass membrane protein (By similarity): P97287 |
Total number of polymer chains | 2 |
Total formula weight | 21405.38 |
Authors | Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.S.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. (deposition date: 2006-10-17, release date: 2007-03-20, Last modification date: 2023-12-20) |
Primary citation | Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.S.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. Structural insights into the degradation of Mcl-1 induced by BH3 domains Proc.Natl.Acad.Sci.Usa, 104:6217-6222, 2007 Cited by PubMed: 17389404DOI: 10.1073/pnas.0701297104 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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