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2JM6

Solution structure of MCL-1 complexed with NOXAB

Functional Information from GO Data
ChainGOidnamespacecontents
A0001836biological_processrelease of cytochrome c from mitochondria
A0006915biological_processapoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0006974biological_processDNA damage response
B0042981biological_processregulation of apoptotic process
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues20
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFkDGvtNWGRIVTLIsFGA
ChainResidueDetails
BVAL234-ALA253

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV
ChainResidueDetails
BTRP286-VAL297

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN
ChainResidueDetails
BALA190-ASN204

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q07820
ChainResidueDetails
BLYS175
BLYS178

223166

PDB entries from 2024-07-31

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