7JGV

CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2

Summary for 7JGV

Entry DOI	10.2210/pdb7jgv/pdb
Descriptor	Bcl-2-like protein 1, 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid (3 entities in total)
Functional Keywords	poptosis, alternative splicing, membrane, mitochondrion, apoptosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	37071.35
Authors	Lee, M.,Fairlie, W.D.,Smith, B.J.,Lee, E.F. (deposition date: 2020-07-19, release date: 2021-02-24, Last modification date: 2023-10-18)
Primary citation	Nguyen, W.,Lee, E.F.,Evangelista, M.,Lee, M.,Harris, T.J.,Colman, P.M.,Smith, N.A.,Williams, L.B.,Jarman, K.E.,Lowes, K.N.,Haeberli, C.,Keiser, J.,Smith, B.J.,Fairlie, W.D.,Sleebs, B.E. Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7:1143-1163, 2021 Cited by PubMed: 33523649 DOI: 10.1021/acsinfecdis.0c00700 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation