Author results

3FK6
  • Download 3fk6
  • View 3fk6
Molmil generated image of 3fk6
CRYSTAL STRUCTURE OF TETR TRIPLE MUTANT (H64K, S135L, S138I)
Descriptor:Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D
Authors:Klieber, M.A., Scholz, O., Lochner, S., Gmeiner, P., Hillen, W., Muller, Y.A.
Deposit date:2008-12-16
Release date:2009-10-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
Febs J., 276, 2009
3FK7
  • Download 3fk7
  • View 3fk7
Molmil generated image of 3fk7
CRYSTAL STRUCTURE OF TETR TRIPLE MUTANT (H64K, S135L, S138I) IN COMPLEX WITH 4-DDMA-ATC
Descriptor:Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D, MAGNESIUM ION, ...
Authors:Klieber, M.A., Scholz, O., Lochner, S., Gmeiner, P., Hillen, W., Muller, Y.A.
Deposit date:2008-12-16
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
Febs J., 276, 2009
3PDS
  • Download 3pds
  • View 3pds
Molmil generated image of 3pds
IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
Descriptor:Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ...
Authors:Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
Deposit date:2010-10-24
Release date:2011-01-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
4MQS
  • Download 4mqs
  • View 4mqs
Molmil generated image of 4mqs
STRUCTURE OF ACTIVE HUMAN M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO THE AGONIST IPEROXO
Descriptor:Muscarinic acetylcholine receptor M2, Nanobody 9-8, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
Authors:Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K.
Deposit date:2013-09-16
Release date:2013-11-27
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
4MQT
  • Download 4mqt
  • View 4mqt
Molmil generated image of 4mqt
STRUCTURE OF ACTIVE HUMAN M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO THE AGONIST IPEROXO AND ALLOSTERIC MODULATOR LY2119620
Descriptor:Muscarinic acetylcholine receptor M2, Nanobody 9-8, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, ...
Authors:Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K.
Deposit date:2013-09-16
Release date:2013-11-27
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
4QKX
  • Download 4qkx
  • View 4qkx
Molmil generated image of 4qkx
STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO A COVALENT AGONIST AND AN ENGINEERED NANOBODY
Descriptor:Beta-2 adrenergic receptor, R9 protein, SODIUM ION, ...
Authors:Weichert, D., Kruse, A.C., Manglik, A., Hiller, C., Zhang, C., Huebner, H., Kobilka, B.K., Gmeiner, P.
Deposit date:2014-06-10
Release date:2014-07-23
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Covalent agonists for studying G protein-coupled receptor activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
5C1M
  • Download 5c1m
  • View 5c1m
Molmil generated image of 5c1m
CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE AGONIST BU72
Descriptor:Mu-type opioid receptor, Nanobody 39, (2S,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, ...
Authors:Huang, W.J., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R., Granier, S., Gmeiner, P., Husbands, S.M., Traynor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilka, B.K.
Deposit date:2015-06-15
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into mu-opioid receptor activation.
Nature, 524, 2015
5ZHP
  • Download 5zhp
  • View 5zhp
Molmil generated image of 5zhp
M3 MUSCARINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH A SELECTIVE ANTAGONIST
Descriptor:Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, TETRAETHYLENE GLYCOL, MALTOSE, ...
Authors:Liu, H., Hofmann, J., Fish, I., Schaake, B., Eitel, K., Bartuschat, A., Kaindl, J., Rampp, H., Banerjee, A., Hubner, H., Clark, M.J., Vincent, S.G., Fisher, J., Heinrich, M., Hirata, K., Liu, X., Sunahara, R.K., Shoichet, B.K., Kobilka, B.K., Gmeiner, P.
Deposit date:2018-03-13
Release date:2018-11-28
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018