3FK6 | | CRYSTAL STRUCTURE OF TETR TRIPLE MUTANT (H64K, S135L, S138I) | | Descriptor: | Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D | | Authors: | Klieber, M.A., Scholz, O., Lochner, S., Gmeiner, P., Hillen, W., Muller, Y.A. | | Deposit date: | 2008-12-16 | | Release date: | 2009-10-27 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
Febs J., 276, 2009
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3FK7 | | CRYSTAL STRUCTURE OF TETR TRIPLE MUTANT (H64K, S135L, S138I) IN COMPLEX WITH 4-DDMA-ATC | | Descriptor: | Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D, MAGNESIUM ION, ... | | Authors: | Klieber, M.A., Scholz, O., Lochner, S., Gmeiner, P., Hillen, W., Muller, Y.A. | | Deposit date: | 2008-12-16 | | Release date: | 2009-11-03 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
Febs J., 276, 2009
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3PDS | | IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX | | Descriptor: | Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ... | | Authors: | Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K. | | Deposit date: | 2010-10-24 | | Release date: | 2011-01-12 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
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4MQS | | STRUCTURE OF ACTIVE HUMAN M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO THE AGONIST IPEROXO | | Descriptor: | Muscarinic acetylcholine receptor M2, Nanobody 9-8, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium | | Authors: | Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K. | | Deposit date: | 2013-09-16 | | Release date: | 2013-11-27 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
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4MQT | | STRUCTURE OF ACTIVE HUMAN M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO THE AGONIST IPEROXO AND ALLOSTERIC MODULATOR LY2119620 | | Descriptor: | Muscarinic acetylcholine receptor M2, Nanobody 9-8, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, ... | | Authors: | Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K. | | Deposit date: | 2013-09-16 | | Release date: | 2013-11-27 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
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4QKX | | STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO A COVALENT AGONIST AND AN ENGINEERED NANOBODY | | Descriptor: | Beta-2 adrenergic receptor, R9 protein, SODIUM ION, ... | | Authors: | Weichert, D., Kruse, A.C., Manglik, A., Hiller, C., Zhang, C., Huebner, H., Kobilka, B.K., Gmeiner, P. | | Deposit date: | 2014-06-10 | | Release date: | 2014-07-23 | | Last modified: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Covalent agonists for studying G protein-coupled receptor activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5C1M | | CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE AGONIST BU72 | | Descriptor: | Mu-type opioid receptor, Nanobody 39, (2S,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, ... | | Authors: | Huang, W.J., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R., Granier, S., Gmeiner, P., Husbands, S.M., Traynor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilka, B.K. | | Deposit date: | 2015-06-15 | | Release date: | 2015-08-05 | | Last modified: | 2017-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into mu-opioid receptor activation.
Nature, 524, 2015
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5ZHP | | M3 MUSCARINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH A SELECTIVE ANTAGONIST | | Descriptor: | Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, TETRAETHYLENE GLYCOL, MALTOSE, ... | | Authors: | Liu, H., Hofmann, J., Fish, I., Schaake, B., Eitel, K., Bartuschat, A., Kaindl, J., Rampp, H., Banerjee, A., Hubner, H., Clark, M.J., Vincent, S.G., Fisher, J., Heinrich, M., Hirata, K., Liu, X., Sunahara, R.K., Shoichet, B.K., Kobilka, B.K., Gmeiner, P. | | Deposit date: | 2018-03-13 | | Release date: | 2018-11-28 | | Last modified: | 2018-12-05 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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