3FK7

Crystal structure of TetR triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc

Summary for 3FK7

Entry DOI	10.2210/pdb3fk7/pdb
Related	2O7O 2TCT 2VKE 2VKV 3FK6
Descriptor	Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D, MAGNESIUM ION, (4aS,12aS)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide, ... (4 entities in total)
Functional Keywords	tetracycline repressor, bacterial transcription regulation, altered inducer specificity, 4-de-dimethylamino-anhydrotetracycline, antibiotic resistance, dna-binding, magnesium, metal-binding, repressor, transcription, transcription regulation, transposable element
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	47712.91
Authors	Klieber, M.A.,Scholz, O.,Lochner, S.,Gmeiner, P.,Hillen, W.,Muller, Y.A. (deposition date: 2008-12-16, release date: 2009-11-03, Last modification date: 2023-11-01)
Primary citation	Klieber, M.A.,Scholz, O.,Lochner, S.,Gmeiner, P.,Hillen, W.,Muller, Y.A. Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. Febs J., 276:5610-5621, 2009 Cited by PubMed: 19712110 DOI: 10.1111/j.1742-4658.2009.07254.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation