2VKV
TetR (BD) variant L17G with reverse phenotype
Summary for 2VKV
Entry DOI | 10.2210/pdb2vkv/pdb |
Related | 1A6I 1BJ0 1BJY 1BJZ 1DU7 1ORK 1QPI 2TCT 2TRT 2VKE |
Descriptor | TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D, 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | transcription, transcription regulation, disorder to order mechanism, antibiotic resistance, helix-turn-helix motif, bacterial repressor, anhydrotetracycline, metal-binding, reverse phenotype, tetr, plasmid, repressor, magnesium, dna-binding |
Biological source | ESCHERICHIA COLI |
Total number of polymer chains | 1 |
Total formula weight | 23824.53 |
Authors | Resch, M.,Striegl, H.,Henssler, E.M.,Sevvana, M.,Egerer-Sieber, C.,Schiltz, E.,Hillen, W.,Muller, Y.A. (deposition date: 2008-01-02, release date: 2008-07-08, Last modification date: 2023-12-13) |
Primary citation | Resch, M.,Striegl, H.,Henssler, E.M.,Sevvana, M.,Egerer-Sieber, C.,Schiltz, E.,Hillen, W.,Muller, Y.A. A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr. Nucleic Acids Res., 36:4390-, 2008 Cited by PubMed: 18587152DOI: 10.1093/NAR/GKN400 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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