2VKV

TetR (BD) variant L17G with reverse phenotype

Summary for 2VKV

Entry DOI	10.2210/pdb2vkv/pdb
Related	1A6I 1BJ0 1BJY 1BJZ 1DU7 1ORK 1QPI 2TCT 2TRT 2VKE
Descriptor	TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D, 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	transcription, transcription regulation, disorder to order mechanism, antibiotic resistance, helix-turn-helix motif, bacterial repressor, anhydrotetracycline, metal-binding, reverse phenotype, tetr, plasmid, repressor, magnesium, dna-binding
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	23824.53
Authors	Resch, M.,Striegl, H.,Henssler, E.M.,Sevvana, M.,Egerer-Sieber, C.,Schiltz, E.,Hillen, W.,Muller, Y.A. (deposition date: 2008-01-02, release date: 2008-07-08, Last modification date: 2023-12-13)
Primary citation	Resch, M.,Striegl, H.,Henssler, E.M.,Sevvana, M.,Egerer-Sieber, C.,Schiltz, E.,Hillen, W.,Muller, Y.A. A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr. Nucleic Acids Res., 36:4390-, 2008 Cited by PubMed: 18587152 DOI: 10.1093/NAR/GKN400 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation