Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1HZH
DownloadVisualize
BU of 1hzh by Molmil
CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
Descriptor: IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saphire, E.O, Burton, D.R, Wilson, I.A.
Deposit date:2001-01-24
Release date:2001-08-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science, 293, 2001
1N0X
DownloadVisualize
BU of 1n0x by Molmil
Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, B2.1 peptide, GLYCEROL, ...
Authors:Saphire, E.O, Montero, M, Menendez, A, Irving, M.B, Zwick, M.B, Parren, P.W.H.I, Burton, D.R, Scott, J.K, Wilson, I.A.
Deposit date:2002-10-15
Release date:2004-04-13
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope
To be Published
6P91
DownloadVisualize
BU of 6p91 by Molmil
Structure of Lassa virus glycoprotein bound to Fab 18.5C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 18.5C Antibody heavy chain, ...
Authors:Saphire, E.O, Hastie, K.M.
Deposit date:2019-06-09
Release date:2019-08-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
6P95
DownloadVisualize
BU of 6p95 by Molmil
Structure of Lassa virus glycoprotein in complex with Fab 25.6A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saphire, E.O, Hastie, K.M.
Deposit date:2019-06-09
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
3S88
DownloadVisualize
BU of 3s88 by Molmil
Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6
Descriptor: 16F6 - Heavy chain, 16F6 - Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saphire, E.O, Dias, J.M, Bale, S.
Deposit date:2011-05-27
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:A shared structural solution for neutralizing ebolaviruses.
Nat.Struct.Mol.Biol., 18, 2011
3VE0
DownloadVisualize
BU of 3ve0 by Molmil
Crystal structure of Sudan Ebolavirus Glycoprotein (strain Boniface) bound to 16F6
Descriptor: 16F6 Antibody chain A, 16F6 Antibody chain B, Envelope glycoprotein, ...
Authors:Saphire, E.O, Bale, S, Dias, J.M.
Deposit date:2012-01-06
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.353 Å)
Cite:Structural basis for differential neutralization of ebolaviruses.
Viruses, 4, 2012
4OR8
DownloadVisualize
BU of 4or8 by Molmil
Crystal structure of Marburg virus VP24
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P, Bornholdt, Z, Abelson, D, Saphire, E.O.
Deposit date:2014-02-11
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.654 Å)
Cite:Crystal Structure of Marburg Virus VP24.
J.Virol., 88, 2014
5INE
DownloadVisualize
BU of 5ine by Molmil
Crystal structure of the prefusion glycoprotein of LCMV
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pre-glycoprotein polyprotein GP complex, ...
Authors:Hastie, K.M, Saphire, E.O.
Deposit date:2016-03-07
Release date:2016-04-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV.
Nat.Struct.Mol.Biol., 23, 2016
4ZTA
DownloadVisualize
BU of 4zta by Molmil
Ebola virus nucleoprotein bound to VP35 chaperoning peptide I212121
Descriptor: Polymerase cofactor VP35,Nucleoprotein
Authors:Kirchdoerfer, R.N, Abelson, D.M, Saphire, E.O.
Deposit date:2015-05-14
Release date:2015-05-27
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ebola virus nucleoprotein bound to VP35 chaperoning peptide I212121
to be published
5HJ3
DownloadVisualize
BU of 5hj3 by Molmil
Crystal structure of host-primed Ebola virus GP, GPcl.
Descriptor: Envelope glycoprotein, KZ52 Antibody Fragment, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bornholdt, Z.A, Fusco, M.L, Saphire, E.O.
Deposit date:2016-01-12
Release date:2016-03-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
Mbio, 7, 2016
2QHR
DownloadVisualize
BU of 2qhr by Molmil
Crystal structure of the 13F6-1-2 Fab fragment bound to its Ebola virus glycoprotein peptide epitope.
Descriptor: 13F6-1-2 Fab fragment V lambda x light chain, 13F6-1-2 Fab fragment heavy chain, Envelope glycoprotein peptide
Authors:Lee, J.E, Kuehne, A, Abelson, D.M, Fusco, M.L, Hart, M.K, Saphire, E.O.
Deposit date:2007-07-02
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
J.Mol.Biol., 375, 2008
3Q7C
DownloadVisualize
BU of 3q7c by Molmil
Exonuclease domain of Lassa virus nucleoprotein bound to manganese
Descriptor: MANGANESE (II) ION, Nucleoprotein, PHOSPHATE ION, ...
Authors:Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O.
Deposit date:2011-01-04
Release date:2011-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Proc.Natl.Acad.Sci.USA, 108, 2011
7SWD
DownloadVisualize
BU of 7swd by Molmil
Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Descriptor: 1C11 scFv, 1C3 heavy chain, 1C3 light chain, ...
Authors:Milligan, J.C, Yu, X, Saphire, E.O.
Deposit date:2021-11-19
Release date:2022-04-06
Last modified:2022-08-10
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Cell, 185, 2022
4GHA
DownloadVisualize
BU of 4gha by Molmil
Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA
Descriptor: Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3')
Authors:Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
4FVU
DownloadVisualize
BU of 4fvu by Molmil
Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease
Descriptor: MAGNESIUM ION, Nucleoprotein, RNA (5'-R(*CP*UP*CP*CP*CP*UP*CP*C)-3'), ...
Authors:Hastie, K.M, King, L.B, Zandonatti, M.A, Saphire, E.O.
Deposit date:2012-06-29
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease.
Plos One, 7, 2012
4GH9
DownloadVisualize
BU of 4gh9 by Molmil
Crystal structure of Marburg virus VP35 RNA binding domain
Descriptor: ACETATE ION, Polymerase cofactor VP35
Authors:Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
7N6P
DownloadVisualize
BU of 7n6p by Molmil
Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab
Descriptor: 1C3 Fab heavy chain, 1C3 Fab light chain
Authors:Milligan, J.C, Yu, X, Buck, T, Saphire, E.O.
Deposit date:2021-06-08
Release date:2022-04-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Cell, 185, 2022
5B0V
DownloadVisualize
BU of 5b0v by Molmil
Crystal Structure of Marburg virus VP40 Dimer
Descriptor: ETHANOL, Matrix protein VP40
Authors:Oda, S, Bornholdt, Z.A, Abelson, D.M, Saphire, E.O.
Deposit date:2015-11-05
Release date:2016-01-20
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression
J.Virol., 90, 2015
3INU
DownloadVisualize
BU of 3inu by Molmil
Crystal structure of an unbound KZ52 neutralizing anti-Ebolavirus antibody.
Descriptor: GLYCEROL, KZ52 antibody fragment heavy chain, KZ52 antibody fragment light chain, ...
Authors:Lee, J.E, Fusco, M.L, Abelson, D.M, Hessell, A.J, Burton, D.R, Saphire, E.O.
Deposit date:2009-08-12
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta Crystallogr.,Sect.D, 65, 2009
3KS4
DownloadVisualize
BU of 3ks4 by Molmil
Crystal structure of Reston ebolavirus VP35 RNA binding domain
Descriptor: Polymerase cofactor VP35
Authors:Kimberlin, C.R, Bornholdt, Z.A, Li, S, Woods, V.L, Macrae, I.J, Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
3KS8
DownloadVisualize
BU of 3ks8 by Molmil
Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA
Descriptor: 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35
Authors:Kimberlin, C.R, Bornholdt, Z.A, Li, S, Woods, V.L, Macrae, I.J, Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
6BP2
DownloadVisualize
BU of 6bp2 by Molmil
Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ...
Authors:King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O.
Deposit date:2017-11-21
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.172 Å)
Cite:The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
2Y6S
DownloadVisualize
BU of 2y6s by Molmil
Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope
Descriptor: ENVELOPE GLYCOPROTEIN, HEAVY CHAIN, LIGHT CHAIN
Authors:Olal, D.O, Kuehne, A, Lee, J.E, Bale, S, Dye, J.M, Saphire, E.O.
Deposit date:2011-01-25
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope.
J.Virol., 86, 2012
4ZTG
DownloadVisualize
BU of 4ztg by Molmil
Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121
Descriptor: Polymerase cofactor VP35,Nucleoprotein fusion protein
Authors:Kirchdoerfer, R.N, Abelson, D.M, Saphire, E.O.
Deposit date:2015-05-14
Release date:2015-05-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121
to be published
4ZTI
DownloadVisualize
BU of 4zti by Molmil
Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121
Descriptor: Polymerase cofactor VP35,Nucleoprotein
Authors:Kirchdoerfer, R.N, Abelson, D.M, Saphire, E.O.
Deposit date:2015-05-14
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121
to be published

225399

PDB entries from 2024-09-25

PDB statisticsPDBj update infoContact PDBjnumon