4GH9

Crystal structure of Marburg virus VP35 RNA binding domain

Summary for 4GH9

Entry DOI	10.2210/pdb4gh9/pdb
Related	3FKE 3KS8 3L25 3L26 3L2A 4GHA
Descriptor	Polymerase cofactor VP35, ACETATE ION (3 entities in total)
Functional Keywords	viral polymerase, interferon inhibition, double stranded viral rna, viral protein, rna binding protein
Biological source	Marburg virus (MARV)
Cellular location	Virion: P35259
Total number of polymer chains	1
Total formula weight	16656.87
Authors	Bale, S.,Jean-Philippe, J.,Bornholdt, Z.A.,Kimberlin, C.K.,Halfmann, P.,Zandonatti, M.A.,Kunert, J.,Kroon, G.J.A.,Kawaoka, Y.,MacRae, I.J.,Wilson, I.A.,Saphire, E.O. (deposition date: 2012-08-07, release date: 2012-08-15, Last modification date: 2023-09-13)
Primary citation	Bale, S.,Julien, J.P.,Bornholdt, Z.A.,Kimberlin, C.R.,Halfmann, P.,Zandonatti, M.A.,Kunert, J.,Kroon, G.J.,Kawaoka, Y.,Macrae, I.J.,Wilson, I.A.,Saphire, E.O. Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism. Plos Pathog., 8:e1002916-e1002916, 2012 Cited by PubMed: 23028316 DOI: 10.1371/journal.ppat.1002916 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation