3Q7C

Exonuclease domain of Lassa virus nucleoprotein bound to manganese

Summary for 3Q7C

• Entry DOI: 10.2210/pdb3q7c/pdb
• Related: 3Q7B
• Descriptor: Nucleoprotein, ZINC ION, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: deddh exonuclease, 3' exonuclease, arenavirus nucleoprotein, hydrolase
• Biological source: Lassa virus (LASV)
• Cellular location: Virion: P13699
• Total number of polymer chains: 1
• Total formula weight: 27485.42

Authors

Hastie, K.M.,Kimberlin, C.R.,Zandonatti, M.A.,MacRae, I.J.,Saphire, E.O. (deposition date: 2011-01-04, release date: 2011-02-09, Last modification date: 2024-02-21)

• Primary citation: Hastie, K.M.,Kimberlin, C.R.,Zandonatti, M.A.,Macrae, I.J.,Saphire, E.O.; Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.; Proc.Natl.Acad.Sci.USA, 108:2396-2401, 2011; PubMed: 21262835; DOI: 10.1073/pnas.1016404108

Experimental method

X-RAY DIFFRACTION (1.5 Å)