4OR8

Crystal structure of Marburg virus VP24

Summary for 4OR8

• Entry DOI: 10.2210/pdb4or8/pdb
• Descriptor: Membrane-associated protein VP24 (2 entities in total)
• Functional Keywords: marburg, vp24, pyramidal fold, protein, ebola, virus, viral, viral protein
• Biological source: Marburg virus - Musoke, Kenya, 1980 (MARV)
• Cellular location: Virion membrane; Peripheral membrane protein: P35256
• Total number of polymer chains: 2
• Total formula weight: 60774.45

Authors

Zhang, A.P.P.,Bornholdt, Z.,Abelson, D.,Saphire, E.O. (deposition date: 2014-02-11, release date: 2014-03-26, Last modification date: 2024-02-28)

Primary citation

Zhang, A.P.,Bornholdt, Z.A.,Abelson, D.M.,Saphire, E.O.
Crystal Structure of Marburg Virus VP24.
J.Virol., 88:5859-5863, 2014

PubMed Abstract: The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting β-shelf and an alternate conformation of the N-terminal polypeptide.

PubMed: 24574400
DOI: 10.1128/JVI.03565-13

Experimental method

X-RAY DIFFRACTION (2.654 Å)