1HZH
CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
Summary for 1HZH
Entry DOI | 10.2210/pdb1hzh/pdb |
Descriptor | IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | immunoglobulin, antibody, b12, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P0DOX5 |
Total number of polymer chains | 4 |
Total formula weight | 151628.99 |
Authors | Saphire, E.O.,Burton, D.R.,Wilson, I.A. (deposition date: 2001-01-24, release date: 2001-08-15, Last modification date: 2020-07-29) |
Primary citation | Saphire, E.O.,Parren, P.W.,Pantophlet, R.,Zwick, M.B.,Morris, G.M.,Rudd, P.M.,Dwek, R.A.,Stanfield, R.L.,Burton, D.R.,Wilson, I.A. Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science, 293:1155-1159, 2001 Cited by PubMed: 11498595DOI: 10.1126/science.1061692 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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