1HZH
CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| L | 0002250 | biological_process | adaptive immune response |
| L | 0002376 | biological_process | immune system process |
| L | 0003823 | molecular_function | antigen binding |
| L | 0005515 | molecular_function | protein binding |
| L | 0005576 | cellular_component | extracellular region |
| L | 0005615 | cellular_component | extracellular space |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006955 | biological_process | immune response |
| L | 0016064 | biological_process | immunoglobulin mediated immune response |
| L | 0019814 | cellular_component | immunoglobulin complex |
| L | 0050853 | biological_process | B cell receptor signaling pathway |
| L | 0070062 | cellular_component | extracellular exosome |
| L | 0071735 | cellular_component | IgG immunoglobulin complex |
| L | 0071738 | cellular_component | IgD immunoglobulin complex |
| L | 0071742 | cellular_component | IgE immunoglobulin complex |
| L | 0071745 | cellular_component | IgA immunoglobulin complex |
| L | 0071753 | cellular_component | IgM immunoglobulin complex |
| L | 0072562 | cellular_component | blood microparticle |
| M | 0002250 | biological_process | adaptive immune response |
| M | 0002376 | biological_process | immune system process |
| M | 0003823 | molecular_function | antigen binding |
| M | 0005515 | molecular_function | protein binding |
| M | 0005576 | cellular_component | extracellular region |
| M | 0005615 | cellular_component | extracellular space |
| M | 0005886 | cellular_component | plasma membrane |
| M | 0006955 | biological_process | immune response |
| M | 0016064 | biological_process | immunoglobulin mediated immune response |
| M | 0019814 | cellular_component | immunoglobulin complex |
| M | 0050853 | biological_process | B cell receptor signaling pathway |
| M | 0070062 | cellular_component | extracellular exosome |
| M | 0071735 | cellular_component | IgG immunoglobulin complex |
| M | 0071738 | cellular_component | IgD immunoglobulin complex |
| M | 0071742 | cellular_component | IgE immunoglobulin complex |
| M | 0071745 | cellular_component | IgA immunoglobulin complex |
| M | 0071753 | cellular_component | IgM immunoglobulin complex |
| M | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR206-HIS212 | |
| H | PHE454-HIS460 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 93 |
| Details | Domain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 198 |
| Details | Domain: {"description":"Ig-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 192 |
| Details | Domain: {"description":"Ig-like 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 97 |
| Details | Region: {"description":"CH1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 11 |
| Details | Region: {"description":"Hinge"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 224 |
| Details | Region: {"description":"CH2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19358553","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29449492","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 190 |
| Details | Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 329 |
| Details | Region: {"description":"Constant (C) domain","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"826475","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
