1HZH

CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016020	cellular_component	membrane
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
M	0002250	biological_process	adaptive immune response
M	0002376	biological_process	immune system process
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0016020	cellular_component	membrane
M	0016064	biological_process	immunoglobulin mediated immune response
M	0019814	cellular_component	immunoglobulin complex
M	0050853	biological_process	B cell receptor signaling pathway
M	0070062	cellular_component	extracellular exosome
M	0071735	cellular_component	IgG immunoglobulin complex
M	0071738	cellular_component	IgD immunoglobulin complex
M	0071742	cellular_component	IgE immunoglobulin complex
M	0071745	cellular_component	IgA immunoglobulin complex
M	0071753	cellular_component	IgM immunoglobulin complex
M	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR206-HIS212
H	PHE454-HIS460

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:11406581, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19358553, ECO:0000269|PubMed:20357243

Chain	Residue	Details
H	ASN314
K	ASN314

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