1HZH

CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (H, K)	IMMUNOGLOBULIN HEAVY CHAIN	polymer	457	50473.7	2	UniProt (P0DOX5) Pfam (PF07654) UniProt (by SIFTS) (P01857)	Homo sapiens (human)	IGG,Immunoglobulin gamma-1 heavy chain NIE
2	C, D (L, M)	IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein	polymer	215	23707.4	2	UniProt (Q8TCD0) Pfam (PF07654) UniProt (by SIFTS) (P01834)	Homo sapiens (human)
3	E (A)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1641.5	1	In PDB GlyTouCan (G36191CD)
4	F (B)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1625.5	1	In PDB GlyTouCan (G27919IH)
5	G, H, I, J (H, K, L, M)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

H, K: 1 - 110 (PDB: 1HZH)
H, K: 111 - 478 (UniProt: P0DOX5)

PDB	External Database	Details
Ala 225	Val 217	conflict

L, M: 1 - 106 (PDB: 1HZH)
L, M: 107 - 214 (UniProt: Q8TCD0)

PDB	External Database	Details
Arg 202	Ser 227	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	148362.0
Branched	Number of molecules	2
	Total formula weight	3267.0
All*	Total formula weight	151629.0

*Water molecules are not included.