3S88
Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6
Summary for 3S88
| Entry DOI | 10.2210/pdb3s88/pdb |
| Related | 3CSY |
| Descriptor | 16F6 - Heavy chain, Envelope glycoprotein, 16F6 - Light chain, ... (5 entities in total) |
| Functional Keywords | glycosylation, viral membrane, immune system-viral protein complex, immune system/viral protein |
| Biological source | Mus musculus More |
| Cellular location | GP2: Virion membrane; Single-pass type I membrane protein (By similarity). GP1: Virion membrane; Peripheral membrane protein (By similarity). GP2-delta: Secreted (By similarity): 3S88 Q7T9D9 |
| Total number of polymer chains | 4 |
| Total formula weight | 100062.83 |
| Authors | Saphire, E.O.,Dias, J.M.,Bale, S. (deposition date: 2011-05-27, release date: 2011-12-07, Last modification date: 2024-11-06) |
| Primary citation | Dias, J.M.,Kuehne, A.I.,Abelson, D.M.,Bale, S.,Wong, A.C.,Halfmann, P.,Muhammad, M.A.,Fusco, M.L.,Zak, S.E.,Kang, E.,Kawaoka, Y.,Chandran, K.,Dye, J.M.,Saphire, E.O. A shared structural solution for neutralizing ebolaviruses. Nat.Struct.Mol.Biol., 18:1424-1427, 2011 Cited by PubMed Abstract: Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1-GP2 neutralize at a post-internalization step--probably fusion. PubMed: 22101933DOI: 10.1038/nsmb.2150 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.351 Å) |
Structure validation
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