3KS8
Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA
Summary for 3KS8
Entry DOI | 10.2210/pdb3ks8/pdb |
Related | 3FKE 3KS4 |
Descriptor | 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35, ... (4 entities in total) |
Functional Keywords | ebolavirus, rna-binding protein, protein-rna complex, interferon, reston, host cytoplasm, interferon antiviral system evasion, rna replication, rna-binding, transcription, virion, viral protein-rna complex, viral protein/rna |
Biological source | Reston ebolavirus (REBOV) |
Cellular location | Virion: Q8JPY0 |
Total number of polymer chains | 6 |
Total formula weight | 93789.65 |
Authors | Kimberlin, C.R.,Bornholdt, Z.A.,Li, S.,Woods, V.L.,Macrae, I.J.,Saphire, E.O. (deposition date: 2009-11-20, release date: 2010-01-12, Last modification date: 2023-09-06) |
Primary citation | Kimberlin, C.R.,Bornholdt, Z.A.,Li, S.,Woods, V.L.,Macrae, I.J.,Saphire, E.O. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc.Natl.Acad.Sci.USA, 107:314-319, 2009 Cited by PubMed: 20018665DOI: 10.1073/pnas.0910547107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.401 Å) |
Structure validation
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