5HJ3
Crystal structure of host-primed Ebola virus GP, GPcl.
Summary for 5HJ3
Entry DOI | 10.2210/pdb5hj3/pdb |
Descriptor | Envelope glycoprotein, KZ52 Antibody Fragment, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | ebola virus, eov, ebolavirus, gp, glycoprotein, gpcl, cleaved, primed, proteolytically, receptor binding pocket, crest, trough, mr72, kz52, broadly neutralizing, viral protein-immune system complex, viral protein/immune system |
Biological source | Ebola virus sp. More |
Cellular location | GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320 P87666 |
Total number of polymer chains | 16 |
Total formula weight | 336368.72 |
Authors | Bornholdt, Z.A.,Fusco, M.L.,Saphire, E.O. (deposition date: 2016-01-12, release date: 2016-03-09, Last modification date: 2020-07-29) |
Primary citation | Bornholdt, Z.A.,Ndungo, E.,Fusco, M.L.,Bale, S.,Flyak, A.I.,Crowe, J.E.,Chandran, K.,Saphire, E.O. Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies. Mbio, 7:e02154-e02115, 2016 Cited by PubMed: 26908579DOI: 10.1128/mBio.02154-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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