7SWD

Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound

Summary for 7SWD

• Entry DOI: 10.2210/pdb7swd/pdb
• EMDB information: 25471
• Descriptor: Virion spike glycoprotein GP1, Virion spike glycoprotein GP2, 1C11 scFv, ... (6 entities in total)
• Functional Keywords: viral protein, glycoprotein, immune system, antibody, ebola virus, viral protein-immune system complex, viral protein/immune system
• Biological source: Ebola virus - Gabon (1994-1997); More
• Total number of polymer chains: 11
• Total formula weight: 234204.04

Authors

Milligan, J.C.,Yu, X.,Saphire, E.O. (deposition date: 2021-11-19, release date: 2022-04-06, Last modification date: 2022-08-10)

• Primary citation: Milligan, J.C.,Davis, C.W.,Yu, X.,Ilinykh, P.A.,Huang, K.,Halfmann, P.J.,Cross, R.W.,Borisevich, V.,Agans, K.N.,Geisbert, J.B.,Chennareddy, C.,Goff, A.J.,Piper, A.E.,Hui, S.,Shaffer, K.C.L.,Buck, T.,Heinrich, M.L.,Branco, L.M.,Crozier, I.,Holbrook, M.R.,Kuhn, J.H.,Kawaoka, Y.,Glass, P.J.,Bukreyev, A.,Geisbert, T.W.,Worwa, G.,Ahmed, R.,Saphire, E.O.; Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.; Cell, 185:995-1007.e18, 2022; PubMed: 35303429; DOI: 10.1016/j.cell.2022.02.023

Experimental method

ELECTRON MICROSCOPY (3.59 Å)