7N6P

Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab

Summary for 7N6P

Entry DOI	10.2210/pdb7n6p/pdb
Descriptor	1C3 Fab heavy chain, 1C3 Fab light chain (3 entities in total)
Functional Keywords	glycoprotein, immune system, antibody
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	95426.70
Authors	Milligan, J.C.,Yu, X.,Buck, T.,Saphire, E.O. (deposition date: 2021-06-08, release date: 2022-04-06)
Primary citation	Milligan, J.C.,Davis, C.W.,Yu, X.,Ilinykh, P.A.,Huang, K.,Halfmann, P.J.,Cross, R.W.,Borisevich, V.,Agans, K.N.,Geisbert, J.B.,Chennareddy, C.,Goff, A.J.,Piper, A.E.,Hui, S.,Shaffer, K.C.L.,Buck, T.,Heinrich, M.L.,Branco, L.M.,Crozier, I.,Holbrook, M.R.,Kuhn, J.H.,Kawaoka, Y.,Glass, P.J.,Bukreyev, A.,Geisbert, T.W.,Worwa, G.,Ahmed, R.,Saphire, E.O. Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses. Cell, 185:995-1007.e18, 2022 Cited by PubMed: 35303429 DOI: 10.1016/j.cell.2022.02.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation