6BP2

Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein

Summary for 6BP2

DescriptorEnvelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ... (7 entities in total)
Functional Keywordsmarburg, ravn, glycoprotein, complex, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceMarburg marburgvirus
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Total number of polymer chains4
Total molecular weight99720.82
Authors
Primary citation
King, L.B.,Fusco, M.L.,Flyak, A.I.,Ilinykh, P.A.,Huang, K.,Gunn, B.,Kirchdoerfer, R.N.,Hastie, K.M.,Sangha, A.K.,Meiler, J.,Alter, G.,Bukreyev, A.,Crowe, J.E.,Saphire, E.O.
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23:101-109.e4, 2018
PubMed: 29324225 (PDB entries with the same primary citation)
DOI: 10.1016/j.chom.2017.12.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.172 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2836005.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution