Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein

Summary for 6BP2

DescriptorEnvelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ... (7 entities in total)
Functional Keywordsmarburg, ravn, glycoprotein, complex, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceMarburg marburgvirus
Total number of polymer chains4
Total molecular weight99720.82
Primary citation
King, L.B.,Fusco, M.L.,Flyak, A.I.,Ilinykh, P.A.,Huang, K.,Gunn, B.,Kirchdoerfer, R.N.,Hastie, K.M.,Sangha, A.K.,Meiler, J.,Alter, G.,Bukreyev, A.,Crowe, J.E.,Saphire, E.O.
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23:101-109.e4, 2018
PubMed: 29324225 (PDB entries with the same primary citation)
DOI: 10.1016/j.chom.2017.12.003
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2836005.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution