6BP2
Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Envelope glycoprotein | polymer | 250 | 27885.4 | 1 | UniProt (A0A0U2XLP5) Pfam (PF01611) UniProt (by SIFTS) (Q1PDC7) | Marburg marburgvirus | |
| 2 | B (B) | Envelope glycoprotein GP2 | polymer | 202 | 22561.0 | 1 | UniProt (A0A0U2XLP5) Pfam (PF22307) UniProt (by SIFTS) (Q1PDC7) | Marburg marburgvirus | |
| 3 | C (H) | MR191 Fab Heavy Chain | polymer | 229 | 24375.3 | 1 | Homo sapiens (human) | ||
| 4 | D (L) | MR191 Fab Light Chain | polymer | 217 | 22851.2 | 1 | Homo sapiens (Human) | ||
| 5 | E (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | F, H (D, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose | branched | 504.4 | 1 | In PDB GlyTouCan (G72618IM) |
Sequence modifications
A: 17 - 266 (UniProt: A0A0U2XLP5)
B: 436 - 637 (UniProt: A0A0U2XLP5)
| PDB | External Database | Details |
|---|---|---|
| Arg 257 | Met 257 | variant |
| Pro 258 | Asn 258 | variant |
| Ile 260 | Ser 260 | variant |
| Tyr 261 | Ser 261 | variant |
| Phe 262 | Asp 262 | variant |
| Arg 263 | Asp 263 | variant |
| Lys 264 | Glu 264 | variant |
| Lys 265 | Asp 265 | variant |
| Arg 266 | Leu 266 | variant |
| PDB | External Database | Details |
|---|---|---|
| Leu 438 | Phe 438 | engineered mutation |
| Ala 439 | Trp 439 | engineered mutation |
| Gly 445 | Phe 445 | engineered mutation |
| Asn 447 | Phe 447 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97672.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1939.8 | |
| All* | Total formula weight | 99612.7 |
