6BP2

Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Envelope glycoprotein	polymer	250	27885.4	1	UniProt (A0A0U2XLP5) Pfam (PF01611) UniProt (by SIFTS) (Q1PDC7) In PDB	Marburg marburgvirus
2	B	Envelope glycoprotein GP2	polymer	202	22561.0	1	UniProt (A0A0U2XLP5) UniProt (by SIFTS) (Q1PDC7) In PDB	Marburg marburgvirus
3	H	MR191 Fab Heavy Chain	polymer	229	24375.3	1		Homo sapiens (human)
4	L	MR191 Fab Light Chain	polymer	217	22851.2	1		Homo sapiens (Human)
5	C	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	D, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose	branched		504.4	1	In PDB GlyTouCan (G72618IM)

Sequence modifications

A: 17 - 266 (UniProt: A0A0U2XLP5)

PDB	External Database	Details
Arg 257	Met 257	variant
Pro 258	Asn 258	variant
Ile 260	Ser 260	variant
Tyr 261	Ser 261	variant
Phe 262	Asp 262	variant
Arg 263	Asp 263	variant
Lys 264	Glu 264	variant
Lys 265	Asp 265	variant
Arg 266	Leu 266	variant

B: 436 - 637 (UniProt: A0A0U2XLP5)

PDB	External Database	Details
Leu 438	Phe 438	engineered mutation
Ala 439	Trp 439	engineered mutation
Gly 445	Phe 445	engineered mutation
Asn 447	Phe 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	97672.9
Branched	Number of molecules	4
	Total formula weight	1939.8
All*	Total formula weight	99612.7

*Water molecules are not included.