3QY2
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![BU of 3qy2 by Molmil](/molmil-images/mine/3qy2) | Crystal structure of the P93A monomer mutant of S. cerevisiae Cks1 | Descriptor: | CITRATE ANION, Cyclin-dependent kinases regulatory subunit | Authors: | Balog, E.R.M, Saetern, O.C, Finch, W, Hoeft, C.O, Thai, V, Harvey, S.L, Kellogg, D.K, Rubin, S.M. | Deposit date: | 2011-03-02 | Release date: | 2011-06-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | The structure of a monomeric mutant cks protein reveals multiple functions for a conserved hinge-region proline. J.Mol.Biol., 411, 2011
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4LPA
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![BU of 4lpa by Molmil](/molmil-images/mine/4lpa) | Crystal structure of a Cdc6 phosphopeptide in complex with Cks1 | Descriptor: | Cyclin-dependent kinases regulatory subunit | Authors: | McGrath, D.A, Balog, E.R.M, Koivomagi, M, Lucena, R, Mai, M.V, Hirschi, A, Kellogg, D.R, Loog, M, Rubin, S.M. | Deposit date: | 2013-07-15 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Cks confers specificity to phosphorylation-dependent CDK signaling pathways. Nat.Struct.Mol.Biol., 20, 2013
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1SCE
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![BU of 1sce by Molmil](/molmil-images/mine/1sce) | |
1PUC
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![BU of 1puc by Molmil](/molmil-images/mine/1puc) | P13SUC1 IN A STRAND-EXCHANGED DIMER | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, P13SUC1 | Authors: | Khazanovich, N, Bateman, K.S, Chernaia, M, Michalak, M, James, M.N.G. | Deposit date: | 1995-12-08 | Release date: | 1996-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer. Structure, 4, 1996
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1QB3
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![BU of 1qb3 by Molmil](/molmil-images/mine/1qb3) | CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN CKS1 | Descriptor: | CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT | Authors: | Bourne, Y, Watson, M.H, Arvai, A.S, Bernstein, S.L, Reed, S.I, Tainer, J.A. | Deposit date: | 1999-04-30 | Release date: | 2000-08-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure and mutational analysis of the Saccharomyces cerevisiae cell cycle regulatory protein Cks1: implications for domain swapping, anion binding and protein interactions. Structure Fold.Des., 8, 2000
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1DKS
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![BU of 1dks by Molmil](/molmil-images/mine/1dks) | CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE | Descriptor: | CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1, PHOSPHATE ION | Authors: | Bourne, Y, Arvai, A.S, Tainer, J.A. | Deposit date: | 1995-11-22 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J.Mol.Biol., 249, 1995
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1CKS
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1DKT
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![BU of 1dkt by Molmil](/molmil-images/mine/1dkt) | CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 COMPLEX WITH METAVANADATE | Descriptor: | CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1, META VANADATE | Authors: | Bourne, Y, Arvai, A.S, Tainer, J.A. | Deposit date: | 1995-11-22 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J.Mol.Biol., 249, 1995
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2ASS
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![BU of 2ass by Molmil](/molmil-images/mine/2ass) | Crystal structure of the Skp1-Skp2-Cks1 complex | Descriptor: | BENZAMIDINE, Cyclin-dependent kinases regulatory subunit 1, PHOSPHATE ION, ... | Authors: | Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P. | Deposit date: | 2005-08-24 | Release date: | 2005-10-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase. Mol.Cell, 20, 2005
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2AST
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![BU of 2ast by Molmil](/molmil-images/mine/2ast) | Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide | Descriptor: | BENZAMIDINE, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ... | Authors: | Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P. | Deposit date: | 2005-08-24 | Release date: | 2005-10-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase. Mol.Cell, 20, 2005
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8BYL
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![BU of 8byl by Molmil](/molmil-images/mine/8byl) | Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex | Descriptor: | Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ... | Authors: | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M. | Deposit date: | 2022-12-13 | Release date: | 2023-06-28 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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5HQ0
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![BU of 5hq0 by Molmil](/molmil-images/mine/5hq0) | Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... | Authors: | Noble, M.E, Martin, M.P, Korolchuk, S, Brown, N.R, Moukhametzianov, R, Stanley, W.A. | Deposit date: | 2016-01-21 | Release date: | 2016-03-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
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5LQF
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![BU of 5lqf by Molmil](/molmil-images/mine/5lqf) | CDK1/CyclinB1/CKS2 in complex with NU6102 | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... | Authors: | Coxon, C.R, Anscombe, E, Harnor, S.J, Martin, M.P, Carbain, B.J, Hardcastle, I.R, Harlow, L.K, Korolchuk, S, Matheson, C.J, Noble, M.E, Newell, D.R, Turner, D.M, Sivaprakasam, M, Wang, L.Z, Wong, C, Golding, B.T, Griffin, R.J, Endicott, J.A, Cano, C. | Deposit date: | 2016-08-17 | Release date: | 2017-01-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J. Med. Chem., 60, 2017
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7NJ0
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![BU of 7nj0 by Molmil](/molmil-images/mine/7nj0) | CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ... | Authors: | Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A. | Deposit date: | 2021-02-14 | Release date: | 2021-08-04 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature, 596, 2021
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6GU7
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![BU of 6gu7 by Molmil](/molmil-images/mine/6gu7) | CDK1/Cks2 in complex with AZD5438 | Descriptor: | 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2 | Authors: | Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P. | Deposit date: | 2018-06-19 | Release date: | 2018-12-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26, 2019
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8BYA
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![BU of 8bya by Molmil](/molmil-images/mine/8bya) | Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex | Descriptor: | Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ... | Authors: | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E. | Deposit date: | 2022-12-12 | Release date: | 2023-06-28 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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8OR4
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![BU of 8or4 by Molmil](/molmil-images/mine/8or4) | Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | Descriptor: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... | Authors: | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | Deposit date: | 2023-04-13 | Release date: | 2023-06-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
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8OR0
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![BU of 8or0 by Molmil](/molmil-images/mine/8or0) | CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | Descriptor: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... | Authors: | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | Deposit date: | 2023-04-12 | Release date: | 2023-06-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
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7B5R
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![BU of 7b5r by Molmil](/molmil-images/mine/7b5r) | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27 | Descriptor: | Cullin-1, Cyclin-A2, Cyclin-dependent kinase 2, ... | Authors: | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2020-12-07 | Release date: | 2021-02-10 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
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7B5L
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![BU of 7b5l by Molmil](/molmil-images/mine/7b5l) | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 | Descriptor: | 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... | Authors: | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2020-12-04 | Release date: | 2021-02-10 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
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7B5M
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![BU of 7b5m by Molmil](/molmil-images/mine/7b5m) | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-p27~Ub~ARIH1. Transition State 2 | Descriptor: | Cullin-1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ... | Authors: | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2020-12-05 | Release date: | 2021-02-17 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.91 Å) | Cite: | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
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4Y72
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![BU of 4y72 by Molmil](/molmil-images/mine/4y72) | Human CDK1/CyclinB1/CKS2 With Inhibitor | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... | Authors: | Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. | Deposit date: | 2015-02-13 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
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4YC3
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![BU of 4yc3 by Molmil](/molmil-images/mine/4yc3) | CDK1/CyclinB1/CKS2 Apo | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ... | Authors: | Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. | Deposit date: | 2015-02-19 | Release date: | 2016-04-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
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4YC6
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![BU of 4yc6 by Molmil](/molmil-images/mine/4yc6) | CDK1/CKS1 | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1 | Authors: | Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. | Deposit date: | 2015-02-19 | Release date: | 2015-05-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
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6GU6
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![BU of 6gu6 by Molmil](/molmil-images/mine/6gu6) | CDK1/Cks2 in complex with Dinaciclib | Descriptor: | 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2 | Authors: | Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P. | Deposit date: | 2018-06-19 | Release date: | 2018-12-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26, 2019
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