6GU7

CDK1/Cks2 in complex with AZD5438

Summary for 6GU7

• Entry DOI: 10.2210/pdb6gu7/pdb
• Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, ... (4 entities in total)
• Functional Keywords: cdk1, cks2, inhibitor, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 179750.27

Authors

Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (deposition date: 2018-06-19, release date: 2018-12-05, Last modification date: 2024-01-17)

• Primary citation: Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P.; Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.; Cell Chem Biol, 26:121-130.e5, 2019; PubMed: 30472117; DOI: 10.1016/j.chembiol.2018.10.015

Experimental method

X-RAY DIFFRACTION (2.75 Å)