6GU7
CDK1/Cks2 in complex with AZD5438
Summary for 6GU7
Entry DOI | 10.2210/pdb6gu7/pdb |
Descriptor | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | cdk1, cks2, inhibitor, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 179750.27 |
Authors | Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (deposition date: 2018-06-19, release date: 2018-12-05, Last modification date: 2024-01-17) |
Primary citation | Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26:121-130.e5, 2019 Cited by PubMed: 30472117DOI: 10.1016/j.chembiol.2018.10.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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