6GU7

CDK1/Cks2 in complex with AZD5438

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	Cyclin-dependent kinase 1	polymer	302	34553.9	4	UniProt (P06493) Pfam (PF00069) In PDB	Homo sapiens (Human)	CDK1,Cell division control protein 2 homolog,Cell division protein kinase 1,p34 protein kinase
2	B, D, F, H	Cyclin-dependent kinases regulatory subunit 2	polymer	84	10290.8	4	UniProt (P33552) Pfam (PF01111) UniProt (by SIFTS) (K9J4F7) In PDB	Homo sapiens (Human)	CKS-2
3	A	4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine	non-polymer		371.5	1	Chemie (FB8)
4		water	water		18.0	13	Chemie (HOH)

Sequence modifications

A, C, E, G: 1 - 297 (UniProt: P06493)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, D, F, H: 1 - 79 (UniProt: P33552)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	179378.8
Non-Polymers*	Number of molecules	1
	Total formula weight	371.5
All*	Total formula weight	179750.3

*Water molecules are not included.